temperature-sensitive mutation
- temperature-sensitive mutation
-
(= ts mutation)
A type of
conditional mutation in organism,
somatic cell or
virus that makes it possible to study genes whose total
inactivation would be lethal. Such ts mutations can also make possible studies of the effect of reversible switching (by temperature changes) in expression of the mutated gene. The usual mechanism of temperature sensitivity is that the mutated
gene codes for
a protein with
a temperature-dependent conformational instability, so that it possesses normal activity at one temperature (the permissive temperature), but is inactive at
a second (non-permissive) temperature.
Dictionary of molecular biology.
2004.
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